![]() Due to the electrostatic interactions between PA and ODN, ODN release can be controlled by changing PA and ODN concentrations in the PA-ODN gel. AFM and SEM images revealed establishment of the nanofibrous PA-ODN network. The self-assembly of PA-ODN gel was characterized by circular dichroism, rheology, atomic force microscopy (AFM) and scanning electron microscopy (SEM). ![]() In this work, a self-assembled peptide nanofibrous system is formed by mixing a cationic peptide amphiphile (PA) with Bcl-2 antisense oligodeoxynucleotide (ODN), G3139, through electrostatic interactions. Gels composed of nanofibrous peptide network have been previously suggested as carriers for controlled delivery of drugs to improve stability and to provide controlled release, but have not been used for oligonucleotide delivery. Chemical stability, controlled release, and intracellular delivery are crucial factors determining their efficacy. ![]() Antisense oligonucleotides provide a promising therapeutic approach for several disorders including cancer. ![]()
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